Each of the Minor answers begin with a synonym of "small". Each of the Major answers begin with a synonym of "big". Each of the clues at the bottom apply to the end word of one Minor answer and one Major answer. Use the big numbers to index into the full answer for Majors and use the small numbers to index into the full answer for Minors to get the answer TO A GREAT DEGREE.
"Mario Kart 8" character that's an infant version of a princess (4 5) - BABY PEACH
Arachnid in a Sisyphean nursery rhyme (4 5 6) - ITSY BITSY SPIDER
"Lollipop" rapper also known as Weezy (3 5) - LIL WAYNE
Nickname of the constellation that contains the North Star (6 6) - LITTLE DIPPER
Tech company behind Word and Excel (9) - MICROSOFT
1960's London trend with a hemline far above the knee (4-5) - MINI-SKIRT
It makes a full rotation every hour (6 4) - MINUTE HAND